Making use of single-molecule optical and AFM imaging and drive-spectroscopy procedures, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our investigation interests include:
Human Rad51 filaments on double- and one-stranded DNA: correlating frequent and irregular types with recombination functionality.
[Laughs] ‘It was absolutely a terrific chance! At enough time, I used to be effectively conscious that it could go Incorrect Which I could come to be significantly less prosperous, but I just overlooked that. Curiosity has often been my strongest driving power. And luckily everything labored out.’
Our do the job was quickly followed up by Other people, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 printed their findings on transistors created from one- and multi-walled carbon nanotubes in Used Physics Letters.
That could be a desire of mine and we set to work which has a tasty dose of naivety. This is something which will most likely yield breathtaking brings about the lengthier expression, but that doesn't make a difference. You should not only want to operate on the inquiries of tomorrow, but will also on the queries with the working day following tomorrow.’
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes
What distinguishes biology from chemistry is these factors collectively make up a dwelling technique. The secret of explained life, I feel, lies in the interactions, the interaction of those molecules. The large dilemma in regards to the origin of lifestyle remains to be unanswered. How did we at any time evolve from straightforward molecules into the really complex techniques we see now? We have no idea. I would like to operate on these kinds of huge, open up questions.’
Nanopores symbolize a chic and adaptable Device to measure single molecules. We analysis novel detection modes with sound-condition nanopores along with different approaches to measure proteins with nanopores. Projects encompass the following:
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Bulk-surface area coupling identifies the mechanistic link involving Min-protein styles in vivo As well as in vitro
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Nanoscientist Cees Dekker is an amiable and flamboyant man who seems Substantially youthful as opposed to 62 years he basically is – modern glasses, psychedelic shirt, engaging smile – although not just one to waste time. He takes his cees dekker time, but not more than needed.
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2013, managed shaping of Reside bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations inside the handedness of histone tetrasomes